Abstract
Purpose: Previous association studies have investigated whether genetic polymorphisms in HTR1B influenced individuals' susceptibility to major depressive disorder (MDD), anti-depressant response (ADR) and suicidal behavior. However, equivocal evidence was obtained. In this meta-analysis, we aimed to examine the association of HTR1B polymorphisms with risk of MDD, ADR and suicidal behavior.Materials and Methods: Studies evaluating the association between HTR1B polymorphisms and risk of MDD, ADR and suicidal behavior were searched in Pubmed, Ovid Medline, web of science and China National Knowledge Infrastructure databases. Summary odds ratios (ORs), 95 % confidence intervals (CIs) and p-values were calculated using a fixed or random effects model.Results: Meta-analysis findings revealed a significantly increased risk of MDD with rs6296 GC and GC/CC genotypes (GC vs. GG: OR = 1.26, 95% CI, 1.07–1.48; GC/CC vs. GG: OR = 1.22, 95% CI, 1.04–1.43, respectively). Moreover, rs6298 CT genotype was significantly associated with an increased risk of suicidal behavior (CT vs. CC: OR = 1.48, 95% CI, 1.16–1.88). However, both rs6296 and rs130058 were not significant risk factors for lethal suicidal behavior.Conclusion: This meta-analysis identified that rs6296 and rs6298 in HTR1B may be significantly related to the risk of MDD and lethality of suicide attempts, respectively. Further studies are required to assess the markers in larger cohorts.
Highlights
Major depressive disorder (MDD) is a common mental disorder that affects about 216 million people worldwide in 2015 [1]
Thirty records were excluded based on no MDD (n = 17), no HTR1B polymorphisms (n = 4), no human study (n = 1) and review articles (n = 8)
The full-text of the remaining 62 articles was assessed and 41 records were excluded based on no MDD (n = 10), no HTR1B polymorphisms (n = 6), review articles (n = 5), no available data (n = 18) and duplicate data reporting by the same group (n = 2)
Summary
Major depressive disorder (MDD) is a common mental disorder that affects about 216 million people worldwide in 2015 [1]. The serotoninergic pathway has been implicated to play a crucial role in the pathophysiology of MDD, antidepressant response (ADR) and suicidal behavior [9,10,11,12]. Some components of this system, such as serotonin receptor 1A, 1B, 2A, 2B, and 2C, are important regulators of metabolism of 5-hydroxytryptamine (5-HT). The 5-HT1B receptor knockout mice displayed a variety of behavioral paradigms, including lower levels of anxiety [14]
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