A Meta-Analysis for Association of XRCC3 rs861539, MTHFR rs1801133, IL-6 rs1800795, IL-12B rs3212227, TNF-α rs1800629, and TLR9 rs352140 Polymorphisms with Susceptibility to Cervical Carcinoma.

Atiyeh Javaheri,Seyedeh Fatemeh Parsaeian,Fatemeh Asadian,Razieh Sadat Tabatabaie,Seyed Alireza Dastgheib,Hossein Golestanpour,Hossein Neamatzadeh,Sepideh Setayesh,Mojgan Karimi-Zarchi

doi:10.31557/apjcp.2021.22.11.3419

Abstract

Background:In spite of substantial declines in both incidence and mortality rates in the past 50 years, cervical cancer remains one of the leading causes of cancer associated mortality among women globally. We performed this meta-analysis to explore the role of XRCC3 rs861539, MTHFR rs1801133, IL-6 rs1800795, IL-12B rs3212227, TNF-α rs1800629 and TLR9 rs352140 polymorphism with susceptibility to cervical carcinoma. Methods:The search databases include PubMed, SciELO, MedRxiv, Web of Science, Scopus, Cochrane Library, China National Knowledge Infrastructure, and China Biology Medicine disc up to 30 June 2021. The language is limited to English and Chinese. The comparison between the polymorphisms and cervical cancer was assessed using pooled odds ratio (OR) and 95% confidence interval (CI). The data are statistically analyzed by Comprehensive Meta-Analysis (CMA) 2.0 software. Results:A total of 59 studies including seven studies with 1,112 cases and 1,233 controls on XRCC3 rs861539, 14 studies with 2,694 cases and 3349 controls MTHFR rs1801133, four studies with 1,121 cases and 1,109 controls on IL-12B rs3212227, seven studies with 1,452 cases and 2,186 controls on IL-6 rs1800795, 20 studies with 4,781 cases and 4909 controls on TNF-α rs1800629, and seven studies with 1743 cases and 2292 controls on TLR9 rs352140 were included. There was a significant association between XRCC3 RS861539, TNF-α rs1800629, and IL-6 rs1800795 polymorphisms and an increased risk of cervical carcinoma in overall population. However, the MTHFR rs1801133, IL-12B rs3212227 and TLR9 rs352140 polymorphisms were not associated. Conclusion:The pooled analysis showed that XRCC3 RS861539, TNF-α rs1800629, and IL-6 rs1800795 were associated with cervical carcinoma susceptibility, but not MTHFR rs1801133, IL-12B rs3212227 and TLR9 rs352140 polymorphisms.

Highlights

Cancer is one of the main public health problems globally with about 18.1 million new cancer cases and9.6 million cancer deaths in 2018 (Ghelmani et al, 2021; Jarahzadeh et al, 2021; Antikchi et al, 2021)
Our understanding of the genetic basis of cervical cancer is still limited. In this meta-analysis, we explore the role of XRCC3 rs861539, TNF-α rs1800629, and TLR9 rs352140 polymorphisms in susceptibility to cervical cancer
The results showed that no individual study had an influence on the pooled odds ratio (OR) all involved polymorphisms at XRCC3 rs861539, MTHFR rs1801133, and TLR9 rs352140 polymorphisms, suggesting the stability of our findings

Summary

Introduction

Cancer is one of the main public health problems globally with about 18.1 million new cancer cases and9.6 million cancer deaths in 2018 (Ghelmani et al, 2021; Jarahzadeh et al, 2021; Antikchi et al, 2021). In spite of substantial declines in both incidence and mortality rates in the past 50 years, cervical cancer remains one of the leading causes of cancer associated mortality among women globally. We performed this meta-analysis to explore the role of XRCC3 rs861539, MTHFR rs1801133, IL-6 rs1800795, IL-12B rs3212227, TNF-α rs1800629 and TLR9 rs352140 polymorphism with susceptibility to cervical carcinoma. The data are statistically analyzed by Comprehensive Meta-Analysis (CMA) 2.0 software

Methods

Results

Conclusion