Abstract
In the normal menstrual cycle, the functional integrity of the hypothalamic-pituitary-ovarian axis requires the pulsatile secretion of gonadotropin-releasing hormone (GnRH) from the hypothalamus. This hypothalamic hormone, also known as luteinizing hormone-releasing hormone, stimulates pituitary gonadotropin (luteinizing hormone and follicle-stimulating hormone) secretion, promoting ovarian follicular maturation, ovulation, and corpus luteum function.<sup>1,2</sup>When the hypothalamus fails to provide an appropriate GnRH stimulation of the pituitary gland, anovulatory infertility often occurs. Recent advances in neuroendocrine physiology demonstrate that pulsatile GnRH replacement therapy can restore ovulation and fertility. Infertility specialists are learning how to provide pulsatile GnRH therapy for the treatment of hypothalamic hypogonadism in both men and women.<sup>3-5</sup>Recent evidence also suggests that higher-dose pulsatile GnRH treatment may be used to achieve multiple follicular growth for in vitro fertilization therapy, when the collection of several mature oocytes is desired.<sup>6</sup>
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: JAMA: The Journal of the American Medical Association
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
