Abstract
Reproductive function is controlled by the pituitary glycoproteins, luteinizing hormone (LH) and follicle stimulating hormone (FSH). The two hormones are composed of a common α-subunit and distinct β-subunits (1, 2). LH and FSH are secreted by the same pituitary gonadotrope cells, and their synthesis and secretion is controlled by the hypothalamic decapeptide gonadotropin releasing hormone (GnRH). GnRH is secreted into the hypophysial-portal blood in an intermittent manner (3, 4), and this pulsatile secretion is essential for maintaining gonadotropin synthesis and release (5–7). The pattern of pulsatile GnRH secretion changes in various physiologic circumstances (8, 9), and differential secretion of LH and FSH also occurs. Thus, it appears that a single gonadotropin releasing hormone can effect differential secretion of LH and FSH by the pituitary gonadotrope cell. Gonadal steroids can alter the pattern of GnRH secretion and also modify gonadotrope responses to GnRH Inhibin, a gonadal polypeptide, acts directly on the pituitary to selectively inhibit FSH secretion. Other gonadal peptides, such as activin, may also be involved in modifying gonadotrope responses to GnRH. Thus, the differential regulation of LH and FSH synthesis and secretion appears to result from changes in the pattern of the GnRH stimulus together with the direct feedback effects of gonadal steroids and peptides on the gonadotrope.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
