Abstract
Malnutrition inflammation complex syndrome (MICS) occurs commonly in maintenance hemodialysis (MHD) patients and may correlate with increased morbidity and mortality. An optimal, comprehensive, quantitative system that assesses MICS could be a useful measure of clinical status and may be a predictor of outcome in MHD patients. We therefore attempted to develop and validate such an instrument, comparing it with conventional measures of nutrition and inflammation, as well as prospective hospitalization and mortality. Using components of the conventional Subjective Global Assessment (SGA), a semiquantitative scale with three severity levels, the Dialysis Malnutrition Score (DMS), a fully quantitative scoring system consisting of 7 SGA components, with total score ranging between 7 (normal) and 35 (severely malnourished), was recently developed. To improve the DMS, we added three new elements to the 7 DMS components: body mass index, serum albumin level, and total iron-binding capacity to represent serum transferrin level. This new comprehensive Malnutrition-Inflammation Score (MIS) has 10 components, each with four levels of severity, from 0 (normal) to 3 (very severe). The sum of all 10 MIS components ranges from 0 to 30, denoting increasing degree of severity. These scores were compared with anthropometric measurements, near-infrared-measured body fat percentage, laboratory measures that included serum C-reactive protein (CRP), and 12-month prospective hospitalization and mortality rates. Eighty-three outpatients (44 men, 39 women; age, 59 ± 15 years) on MHD therapy for at least 3 months (43 ± 33 months) were evaluated at the beginning of this study and followed up for 1 year. The SGA, DMS, and MIS were assessed simultaneously on all patients by a trained physician. Case-mix-adjusted correlation coefficients for the MIS were significant for hospitalization days (r = 0.45; P < 0.001) and frequency of hospitalization (r = 0.46; P < 0.001). Compared with the SGA and DMS, most pertinent correlation coefficients were stronger with the MIS. The MIS, but not the SGA or DMS, correlated significantly with creatinine level, hematocrit, and CRP level. During the 12-month follow-up, 9 patients died and 6 patients left the cohort. The Cox proportional hazard-calculated relative risk for death for each 10-unit increase in the MIS was 10.43 (95% confidence interval, 2.28 to 47.64; P = 0.002). The MIS was superior to its components or different subversions for predicting mortality. The MIS appears to be a comprehensive scoring system with significant associations with prospective hospitalization and mortality, as well as measures of nutrition, inflammation, and anemia in MHD patients. The MIS may be superior to the conventional SGA and the DMS, as well as to individual laboratory values, as a predictor of dialysis outcome and an indicator of MICS. © 2001 by the National Kidney Foundation, Inc.
Highlights
INDEX WORDS: Dialysis; malnutrition; inflammation; nutritional assessment; hospitalization; mortality; near infrared; albumin; transferrin; C-reactive protein (CRP)
THERE IS A HIGH prevalence of measures of both protein-energy malnutrition and inflammation in patients with end-stage renal disease (ESRD) who are undergoing maintenance hemodialysis (MHD).[1,2,3]
Percentage of body fat, and Kt/V were greater in women, whereas Midarm muscle circumference (MAMC), lean body weight, and serum creatinine levels were greater in men
Summary
INDEX WORDS: Dialysis; malnutrition; inflammation; nutritional assessment; hospitalization; mortality; near infrared; albumin; transferrin; C-reactive protein (CRP). Factors causing protein-energy malnutrition and proinflammatory cytokines, which themselves may cause anorexia, muscle wasting, hypoalbuminemia, refractory anemia, and, possibly, accelerated atherosclerosis, are apparent causes of MICS.[5,6] Several features of MICS, alone or in combination, are strong predictors of degree of sickness, as well as morbidity and mortality, in these patients.[7,8]. DK07219 from the National Institutes of Health (K.K.Z.). Presented in part at the 9th Annual National Kidney Foundation Clinical Meeting, Atlanta, GA, April 2000, and the 10th Annual National Kidney Foundation Clinical Meeting, Orlando, FL, April 2001
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