Abstract
BackgroundVenous thromboembolism (VTE) is a common problem in cancer patients and the incidence is increasing, especially for patients with lung cancer. Common features of these patients, like advanced stage, male gender, old age and chemotherapy, are risk factors of VTE. Here we reported a case in which the patient with lung cancer developed deep vein thrombosis (DVT) when receiving chemotherapy.Case presentationA 53-year-old male who was diagnosed with lung cancer with multiple metastasis developed severe DVT during chemotherapy. Despite the use of aspirin, warfarin and low molecular weight heparin (LMWH) for anticoagulant and thrombolytic therapy, the condition was still deteriorating, resulting in amputation finally.ConclusionsIt’s rare that the conditions of cancer patients who develop venous thromboembolism (VTE) keep deteriorating despite the administration of aspirin, warfarin and low weight molecular heparin. Both early diagnosis and prophylactic use of anticoagulants are suggested for cancer patients to improve the prognosis.
Highlights
Venous thromboembolism (VTE) is a common problem in cancer patients and the incidence is increasing, especially for patients with lung cancer
Venous thromboembolism (VTE), a thrombotic disorder defined as deep vein thrombosis (DVT), pulmonary embolism (PE), or both, is a clinical challenge in patients with malignancies, which has caused unneglectable morbidity and mortality
Cancer patients are predisposed to the development of VTE events with an up to 7% risk, partly due to their considerable exposure to various circumstantial risk factors including surgery, immobilization and medications during the course of their disease
Summary
Venous thromboembolism (VTE), a thrombotic disorder defined as deep vein thrombosis (DVT), pulmonary embolism (PE), or both, is a clinical challenge in patients with malignancies, which has caused unneglectable morbidity and mortality. Among all cancer-related mortality, lung cancer is still the leading cause worldwide, with tobacco intake as the In this case report, we discussed clinical manifestations, risk factors of VTE and treatment procedures in a patient with advanced-stage lung cancer who developed severe DVT and eventually underwent amputation. Computed tomography (CT) indicated malignant lesions of left upper lobe and multiple lymph node metastases in mediastinum, neck, both lungs and right acetabular bone (Fig. 1). 2 days later, the patient described he felt distending pain in the left lower limb. Ultrasound and CT-angiography (CTA) indicated insufficient blood supply to the left lower limb due to compression on arteries by DVT.
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