Abstract
By employment of the flexible bis-(imidazole-4,5-dicarboxylate) ligand (H4L) ligand, a new luminescent Eu(III)-containing coordination polymer {[Eu(HL)(H2O)2]·2(H2O)}n has been successfully synthesized under hydrothermal condition by reaction of Eu(NO3)3·6H2O with H4L with the presence of NaOH as the pH modulator. The chemical composing of the as-prepared complex 1 has been determined via the elemental analysis and the structural arrangement was probed via the single crystal X-ray diffraction. Furthermore, complex 1 could also be applied as a luminescent sensor for the detection of p-nitroaniline, which has high sensitivity and selectivity. In biological research, the related anti-colon cancer activity on SW480 cancer cells was further evaluated. Firstly, the effect of compound on TRIB3 gene expression was evaluated by RT-PCR. The CCK-8 and transwell assay were next be performed to detect the inhibitory function of compound on SW480 cancer cell proliferation and migration. Finally, the results obtained through molecular docking simulation shed light on the understanding of Eu(II) metallic complex on DNA.
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