A low-rank deep image prior reconstruction for free-breathing ungated spiral functional CMR at 0.55T and 1.5T.

Abstract

This study combines a deep image prior with low-rank subspace modeling to enable real-time (free-breathing and ungated) functional cardiac imaging on a commercial 0.55T scanner. The proposed low-rank deep image prior (LR-DIP) uses two u-nets to generate spatial and temporal basis functions that are combined to yield dynamic images, with no need for additional training data. Simulations and scans in 13 healthy subjects were performed at 0.55T and 1.5T using a golden angle spiral bSSFP sequence with images reconstructed using [Formula: see text]-ESPIRiT, low-rank plus sparse (L + S) matrix completion, and LR-DIP. Cartesian breath-held ECG-gated cine images were acquired for reference at 1.5T. Two cardiothoracic radiologists rated images on a 1-5 scale for various categories, and LV function measurements were compared. LR-DIP yielded the lowest errors in simulations, especially at high acceleration factors (R [Formula: see text] 8). LR-DIP ejection fraction measurements agreed with 1.5T reference values (mean bias -0.3% at 0.55T and -0.2% at 1.5T). Compared to reference images, LR-DIP images received similar ratings at 1.5T (all categories above 3.9) and slightly lower at 0.55T (above 3.4). Feasibility of real-time functional cardiac imaging using a low-rank deep image prior reconstruction was demonstrated in healthy subjects on a commercial 0.55T scanner.