Abstract
To optimize high-resolution 7T MRI of the cochlea and measure normal cochlea and the cochlear nerve morphometry in vivo. Eight volunteers with normal hearing were scanned at 7T using an optimized protocol. Two neuroradiologists independently scored image quality. The basal turn lumen diameter (BTLD), height, width, length and volume of the cochlear, long (LD) and short (SD) diameter the calculated cross-sectional area (CSA) of the cochlear nerve were measured. Intra and inter-observer reliability was assessed using intraclass correlation (ICC). 3D T2W DRIVE combined with dielectric pads, allowed acquisition of high-resolution images showing detailed structures, such as the crista ampullaris in the semicircular canals. The overall grading scores from neuroradiologists were excellent. In the left ear, averaging over all subjects gave BTLD of 2.6 ± 0.05mm, height of 4.9 ± 0.1mm, width of 4.4 ± 0.2mm, length of 36.5 ± 0.4mm, volume of 0.16 ± 0.02ml, LD of 1.31 ± 0.1mm, SD of 1.06 ± 0.1mm, and CSA of 1.1 ± 0.1 mm2. The right ear gave BTLD of 2.6 ± 0.04mm, height of 4.9 ± 0.1mm, width of 4.4 ± 0.3mm, length of 35.5 ± 0.4mm, volume of 0.16 ± 0.02ml, LD of 1.29 ± 0.1mm, SD of 1.07 ± 0.1mm, and CSA of 1.10 ± 0.2 mm2. No statistically significant difference was found between the sides of the head (p-value > 0.05). The intra-observer reliability was high (0.77-0.94), while the inter-observer reliability varied from moderate to high (0.55-0.81). 7T MRI can provide excellent visualization of the internal structure of the cochlear and of the vestibulocochlear nerve in vivo.
Published Version
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