A low-protein diet enriched with ketoacids for renal individuals: Implications on nutritional status

Abstract

Patients with stages 3-5 of chronic kidney disease (CKD) should reduce their protein intake, but only if they are metabolically stable, the Clinical Practice Guideline for Nutrition in Chronic Kidney Disease (CKD) by the 2020 Renal Disease Outcome Quality Initiative (KDOQI) states. The objectives include the delay of renal failure (level 1A evidence-supported) and improvement of quality of life (level 2C evidence-supported). Despite these grave cautions, only a small percentage of nephrologists globally promote low-protein diets (LPDs). In this review, we argue that protein restriction is an essential part of treatment for CKD patients rather than a potential therapeutic alternative. LPDs tailored to each patient are critical for maximizing adherence, productivity, and security. When recommending LPDs to patients, nephrologists and renal dietitians may use the same guidelines as doctors when prescribing any other prescription, including considering the drug's indications, contraindications, and mechanism of action, doses, potential adverse effects, and specific cautions. In keeping with this paradigm, we assess the upsides and drawbacks of LPDs as central components of CKD treatment.