Precision Nutrition and Personalized Diet Plan for Kidney Health and Kidney Disease Management

Abstract

Diet and nutrition can help improve overall and kidney health, but they can also cause kidney disease.1Kalantar-Zadeh K. Moore L.W. Does kidney longevity mean healthy vegan food and less meat or is any low-protein diet good enough?.J Ren Nutr. 2019; 29: 79-81Abstract Full Text Full Text PDF PubMed Scopus (24) Google Scholar Evidence suggests that high intake of dietary protein especially from animal sources may increase the risk of chronic kidney disease (CKD)2Ko G.J. Rhee C.M. Kalantar-Zadeh K. Joshi S. The effects of high-protein diets on kidney health and longevity.J Am Soc Nephrol. 2020; 31: 1667-1679Crossref PubMed Scopus (65) Google Scholar in a similar way that high energy intake and presence of obesity often cause diabetes mellitus and cardiovascular disease. Once CKD is present, certain types of foods and other nutritional interventions such as a plant-dominant, low-protein diet or weight and body fat control can help slow the rate of CKD progression.3Kalantar-Zadeh K. Joshi S. Schlueter R. et al.Plant-dominant low-protein diet for conservative management of chronic kidney disease.Nutrients. 2020; 12: E1931Crossref PubMed Scopus (79) Google Scholar In opposition, high-salt, high-protein from animal sources or presence of morbid obesity with high visceral fat can accelerate the development of kidney failure.4Li P.K. Garcia-Garcia G. Lui S.F. et al.World Kidney Day Steering CommitteeKidney health for everyone everywhere-from prevention to detection and equitable access to care.Kidney Int. 2020; 97: 226-232Abstract Full Text Full Text PDF PubMed Scopus (75) Google Scholar,5Kalantar-Zadeh K. Moore L.W. Engaging nutrition and diet for primary, secondary, and tertiary prevention of kidney disease: the world kidney day 2020.J Ren Nutr. 2020; 30: 89-91Abstract Full Text Full Text PDF PubMed Scopus (8) Google Scholar Upon transition to maintenance dialysis therapy, high dietary protein intake may help patients survive longer, while upon successful kidney transplantation, maintaining a plant-dominant low-protein diet and avoiding obesity may confer kidney allograft longevity.6Kalantar-Zadeh K. Moore L.W. Improving muscle strength and preventing sarcopenia and cachexia in chronic kidney disease and transplanted patients by physical activity and exercise.J Ren Nutr. 2019; 29: 465-466Abstract Full Text Full Text PDF PubMed Scopus (11) Google Scholar While patients with stable CKD and slow disease progression and persons with a solitary kidney may benefit from avoiding high protein intake, during an acute kidney injury, including an acute kidney injury on CKD episode, a higher protein intake may be beneficial for faster kidney recovery during this catabolic event, although data are not consistent.7Kalantar-Zadeh K. Moore L.W. Why the nutritional management of acute versus chronic kidney disease should differ.J Ren Nutr. 2019; 29: 265-268Abstract Full Text Full Text PDF PubMed Scopus (7) Google Scholar Certain food constellations may help with specific CKD etiologies. A gluten-free and dairy-free diet may be useful in children with steroid-resistant nephrotic syndrome or focal segmental glomerulosclerosis.8Leon J. Perez-Saez M.J. Uffing A. et al.Effect of combined gluten-free, dairy-free diet in children with steroid-resistant nephrotic syndrome: an open pilot trial.Kidney Int Rep. 2018; 3: 851-860Abstract Full Text Full Text PDF PubMed Scopus (7) Google Scholar Higher fish intake or ingestion of omega-3 fatty acids are recommended for the treatment of IgA nephropathy.9Coppo R. The gut-renal connection in IgA nephropathy.Semin Nephrol. 2018; 38: 504-512Abstract Full Text Full Text PDF PubMed Scopus (46) Google Scholar A ketogenic diet may be promising for polycystic kidney disease.10Torres J.A. Kruger S.L. Broderick C. et al.Ketosis ameliorates renal cyst growth in polycystic kidney disease.Cell Metab. 2019; 30: 1007-1023.e5Abstract Full Text Full Text PDF PubMed Scopus (74) Google Scholar Antioxidant-rich foods can be considered for the prevention of coronavirus disease 2019 and its kidney-associated pathologies.11Kalantar-Zadeh K. Moore L.W. Impact of nutrition and diet on COVID-19 infection and implications for kidney health and kidney disease management.J Ren Nutr. 2020; 30: 179-181Abstract Full Text Full Text PDF PubMed Scopus (40) Google Scholar There are also exotic foods such as fermented Cordyceps fungi, which grow out of the body of certain insects and arthropods and have traditionally been consumed in some Southeast Asian nations to prevent or cure diabetic kidney disease.5Kalantar-Zadeh K. Moore L.W. Engaging nutrition and diet for primary, secondary, and tertiary prevention of kidney disease: the world kidney day 2020.J Ren Nutr. 2020; 30: 89-91Abstract Full Text Full Text PDF PubMed Scopus (8) Google Scholar,12Li Y. Xu G. Clinical efficacy and safety of jinshuibao combined with ACEI/ARB in the treatment of diabetic kidney disease: a meta-analysis of randomized controlled trials.J Ren Nutr. 2020; 30: 92-100Abstract Full Text Full Text PDF PubMed Scopus (10) Google Scholar Hence, in the field of renal nutrition, a one-size-fits-all recipe is nonexistent given different severities, stages, and types of kidney disease. Different persons with the same kidney disease condition and similar stage and severity of CKD may benefit from different types and ranges of dietary intake. For instance, for health management of patients with a solitary kidney, avoiding high protein intake >1 g/kg/day and high body mass index >30 kg/m2 may be generally recommended,13Tantisattamo E. Dafoe D.C. Reddy U.G. et al.Current management of patients with acquired solitary kidney.Kidney Int Rep. 2019; 4: 1205-1218Abstract Full Text Full Text PDF PubMed Scopus (45) Google Scholar whereas for a muscular football player with a solitary kidney, who is professionally engaged in a very high daily dietary protein intake with extraordinary body builder goals, an individualized approach with different dietary protein and body mass index targets are to be considered. Similarly, when a plant-dominant low-protein diet with >50% plant-based sources of protein is recommended for the management of CKD,3Kalantar-Zadeh K. Joshi S. Schlueter R. et al.Plant-dominant low-protein diet for conservative management of chronic kidney disease.Nutrients. 2020; 12: E1931Crossref PubMed Scopus (79) Google Scholar the remaining source of protein can vary from light meat intake as in the Dietary Approaches to Stop Hypertension diet to strictly vegan dieting based on the individualized goals, phenotypes, and genotypes. These personalized approaches are consistent with the concept of Precision Nutrition, which is a type of Precision Medicine with focus on personalized nutrition and dietary adjustments to strive a more patient-centered nutritional management of kidney health and kidney disease.14Rozga M. Handu D. Nutritional genomics in precision nutrition: an evidence analysis center scoping review.J Acad Nutr Diet. 2019; 119: 507-515.e7Abstract Full Text Full Text PDF PubMed Scopus (11) Google Scholar Global kidney health approaches need to be more effectively realigned with the implementation of the principles of precision nutrition including individualized treatment goals across different patients with different phenotypic and genotypic constellations and linking diet and nutrition to the microbiome and environment, as opposed to the traditional one-size-fits-all approach of contemporary renal nutrition.15Hughes R.L. Marco M.L. Hughes J.P. Keim N.L. Kable M.E. The role of the gut microbiome in predicting response to diet and the development of precision nutrition models-Part I: overview of current methods.Adv Nutr. 2019; 10: 953-978Crossref PubMed Scopus (41) Google Scholar,16Moore L.W. Kalantar-Zadeh K. Global approaches to nutrition assessment and intervention for patients with kidney disease.J Ren Nutr. 2020; 30: 271-273Abstract Full Text Full Text PDF PubMed Scopus (5) Google Scholar In this issue of the journal, Brennan et al.17Brennan F. Stevenson J. Brown M. The pathophysiology and management of taste changes in chronic kidney disease: a review.J Ren Nutr. 2020; https://doi.org/10.1053/j.jrn.2019.11.004Abstract Full Text Full Text PDF PubMed Scopus (13) Google Scholar review the role of alterations in taste among persons with CKD and examine the extent and content of prior research around this important but underappreciated nutritional symptom in CKD. Considering Precision Nutrition–based approaches, correcting taste problems is an important goal in the nutritional management of patients with CKD because taste disturbances may interfere with targeted meal plans. In another article of this issue of the journal, St-Jules et al.18St-Jules D.E. Marinaro M. Goldfarb D.S. Byham-Gray L.D. Wilund K.R. Managing hyperkalemia: another benefit of exercise in people with chronic kidney disease?.J Ren Nutr. 2019; https://doi.org/10.1053/j.jrn.2019.10.001Abstract Full Text Full Text PDF Scopus (6) Google Scholar discuss that regular exercise may affect potassium balance favorably in people with CKD. Hence, it is possible, although not yet proven, that exercise may provide additional management options for potassium burden, so that individuals with more physical activity can enjoy even higher intake of fresh fruits and vegetables, which can be considered a personalized diet adjustment in alignment with the principles of Precision Nutrition. Consistent with the goals of Precision Nutrition, Snelson et al.19Snelson M. Biruete A. McFarlane C. Campbell K. A renal clinician's guide to the gut microbiota.J Ren Nutr. 2020; https://doi.org/10.1053/j.jrn.2019.11.002Abstract Full Text Full Text PDF Scopus (14) Google Scholar examine the potential role of diet in modulating gut microbiota composition, which may have a bearing on the progression of CKD and production of uremic toxins, given that worsening uremia per se can alter microbiome. Hence, different dietary patterns such as more plant-based foods along with tailored intake of prebiotics, probiotics, and synbiotics may beneficially alter the microbiota. Nuts are exceptionally rich in fiber and, hence, useful against constipation, but patients on dialysis are often asked to avoid nuts because of their presumably high potassium and phosphorus content. Lambert et al.20Lambert K. Bird L. Borst A.C. et al.Safety and efficacy of using nuts to improve bowel health in hemodialysis patients.J Ren Nutr. 2020; https://doi.org/10.1053/j.jrn.2019.10.002Abstract Full Text Full Text PDF Scopus (8) Google Scholar gave 40 g of raw almonds for 4 weeks to 10 patients on dialysis every day, followed by a 2-week washout and 4-week control periods. The study found that daily intake of almonds was safe, effective, and well tolerated and led to improved health-related quality of life and symptom burden as well as correction of constipation without causing hyperkalemia or hyperphosphatemia. In another study, using food frequency questionnaires, Ajjarapu et al.21Ajjarapu A.S. Hinkle S.N. Wu J. et al.Nut consumption and renal function among women with a history of gestational diabetes.J Ren Nutr. 2020; https://doi.org/10.1053/j.jrn.2019.10.005Abstract Full Text Full Text PDF PubMed Scopus (3) Google Scholar studied 607 women with a history of gestational diabetes mellitus and found an association between higher or more frequent intake of nuts and lower urinary albumin-to-creatinine ratio. They concluded that moderate nut ingestion can be beneficial to kidney health among women with prior gestational diabetes, a finding in alignment with data suggesting that nut intake is associated with reduced cardiometabolic risk.21Ajjarapu A.S. Hinkle S.N. Wu J. et al.Nut consumption and renal function among women with a history of gestational diabetes.J Ren Nutr. 2020; https://doi.org/10.1053/j.jrn.2019.10.005Abstract Full Text Full Text PDF PubMed Scopus (3) Google Scholar Fakier and Rodgers22Fakier S. Rodgers A. Exploring the potential relationship between phytate ingestion, urinary phytate excretion, and renal stone risk in a unique human model: no hard evidence in support of phytate as a stone inhibitor.J Ren Nutr. 2020; https://doi.org/10.1053/j.jrn.2019.10.006Abstract Full Text Full Text PDF PubMed Scopus (4) Google Scholar examine the roles of dietary phytate ingestion and its urinary excretion as they could relate to the risk of calcium kidney stone risk and found that there was no hard evidence in support of phytate as a kidney stone inhibitor. Hoshino et al.23Hoshino J. Muenz D. Zee J. et al.Associations of hemoglobin levels with health-related quality of life, physical activity, and clinical outcomes in persons with stage 3-5 nondialysis CKD.J Ren Nutr. 2020; https://doi.org/10.1053/j.jrn.2019.11.003Abstract Full Text Full Text PDF PubMed Scopus (22) Google Scholar studied data from a prospective cohort of 2,121 persons with CKD stages 3-5 not on dialysis and reported that health-related quality of life was worse in those with more severe anemia defined as hemoglobin <10 g/dL, the odds of being highly physically active were substantially greater at hemoglobin >10.5 g/d, and physical inactivity was strongly associated with greater mortality. These findings may be useful in informing future studies with focus on improving patient well-being and other relevant clinical outcomes. Garcia-Torres et al.24Garcia-Torres R. Young L. Murray D.P. Kheda M. Nahman Jr., N.S. Dietary protein source and phosphate levels in patients on hemodialysis.J Ren Nutr. 2020; https://doi.org/10.1053/j.jrn.2019.11.006Abstract Full Text Full Text PDF PubMed Scopus (8) Google Scholar examined the association of dietary protein and energy intake and serum phosphorus level in 358 patients on dialysis using food frequency questionnaires and found that dietary protein intake and phosphorus level were significantly lower in patients who consumed a primarily plant-based diet than those in patients consuming an animal-based diet. They concluded that consuming more plant-based protein as part of a varied diet could be nutritionally adequate while limiting intake of absorbable dietary phosphorus. Vaz de Melo Ribeiro et al.25Vaz de Melo Ribeiro P. Miranda Hermsdorff H.H. Balbino K.P. de Paula Santos Epifanio A. de Paula Jorge M. Bandeira Moreira A.V. Effect of a nutritional intervention, based on transtheoretical model, on metabolic markers and food consumption of individuals undergoing hemodialysis.J Ren Nutr. 2020; https://doi.org/10.1053/j.jrn.2019.12.004Abstract Full Text Full Text PDF PubMed Scopus (5) Google Scholar studied 83 hemodialysis-dependent persons over 4 months and implemented a nutritional intervention based on the transtheoretical model with delivery of personalized food plans, concordant with Precision Nutrition and nutritional education activities. They observed a significant change from the stage of contemplation to the stage of action after the intervention paralleled with a significant reduction in serum creatinine and urea along with improvements in controlling hyperphosphatemia, hyperkalemia, and other markers of bone and iron metabolism. They concluded that a nutritional intervention based on the transtheoretical model promoted a favorable change in the behavior of these patients with an improvement in their metabolic control as well as adequate use of phosphorus binders. Murtas et al.26Murtas S. Aquilani R. Iadarola P. et al.Differences and effects of metabolic fate of individual amino acid loss in high-efficiency hemodialysis and hemodiafiltration.J Ren Nutr. 2020; https://doi.org/10.1053/j.jrn.2019.12.003Abstract Full Text Full Text PDF PubMed Scopus (10) Google Scholar studied the loss of arterial blood concentration of nonessential, essential, and branched-chain amino acids comparing on-line modern high-efficiency hemodialysis and hemodiafiltration in 10 patients who were randomized to these modalities and reported a reduction of essential and nonessential amino acids, which after 12 months led to progressive deterioration of lean mass and emergence of sarcopenia. Hence, it is possible that amino acid supplementation may be needed to prevent hypercatabolism and cachexia.26Murtas S. Aquilani R. Iadarola P. et al.Differences and effects of metabolic fate of individual amino acid loss in high-efficiency hemodialysis and hemodiafiltration.J Ren Nutr. 2020; https://doi.org/10.1053/j.jrn.2019.12.003Abstract Full Text Full Text PDF PubMed Scopus (10) Google Scholar Beberashvili et al.27Beberashvili I. Samogalska O. Azar A. Stav K. Efrati S. Nutritional status and mortality predictability for time-varying serum alkaline phosphatase in hemodialysis patients: a longitudinal study.J Ren Nutr. 2020; https://doi.org/10.1053/j.jrn.2019.10.004Abstract Full Text Full Text PDF PubMed Scopus (4) Google Scholar examined the mortality-predictability of time-varying serum alkaline phosphatase in 554 patients on hemodialysis over time and found that longitudinally increasing levels of serum alkaline phosphatase was associated with improved nutritional status and lower mortality. Finally, in this issue of the Journal of Renal Nutrition, there is a concise commentary by the International Society of Renal Nutrition and Metabolism (ISRNM) on the National Kidney Foundation and Academy of Nutrition and Dietetics Kidney Disease Outcomes Quality Initiative (KDOQI) Clinical Practice Guideline (CPG) for Nutrition in Chronic Kidney Disease, led by Kistler et al.28Kistler B.M. Moore L.W. Benner D. et al.The International Society of Renal Nutrition and Metabolism Commentary on the National Kidney Foundation and Academy of Nutrition and Dietetics KDOQI clinical Practice guideline for nutrition in chronic kidney disease..J Ren Nutr. 2020; https://doi.org/10.1053/j.jrn.2020.05.002Abstract Full Text Full Text PDF PubMed Scopus (26) Google Scholar on behalf of the ISRNM assembled special review panel of experts, who evaluated these recommendations before public review. As one of the highlights of the CPG, the recommended dietary protein intake range for patients with diabetic kidney disease is 0.6-0.8 g/kg/day, whereas for CKD patients without diabetes, it is 0.55-0.6 g/kg/day.28Kistler B.M. Moore L.W. Benner D. et al.The International Society of Renal Nutrition and Metabolism Commentary on the National Kidney Foundation and Academy of Nutrition and Dietetics KDOQI clinical Practice guideline for nutrition in chronic kidney disease..J Ren Nutr. 2020; https://doi.org/10.1053/j.jrn.2020.05.002Abstract Full Text Full Text PDF PubMed Scopus (26) Google Scholar The ISRNM endorses the KDOQI CPG with the recommendation that clinicians may consider a more streamlined target of 0.6-0.8 g/kg/day regardless of CKD etiology while striving to achieve intakes closer to 0.6 g/kg/day. In addition, we hope that the new KDOQI guidelines are implemented in accordance with the principles of Precision Nutrition including a personalized approach to intake of the dietary protein and other macronutrients and micronutrients.