Abstract

The mismatch negativity (MMN) is considered a promising candidate biomarker of psychosis. Studies have found a reduction of MMN in patients with first-episode psychosis (FEP). Impaired neurocognition (NC), social cognition (SC), and functioning have also been reported. However, few studies have examined longitudinal changes of MMN together with cognitive and functional performances in FEP. We aimed to examine 1) MMN differences between controls and FEP patients at baseline and follow-up, 2) relationships between MMN, NC, SC, and functioning, 3) the predictability of baseline MMN, NC, SC, diagnosis, and symptom to follow-up functioning measures.

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