Abstract
Investigating lipid droplets (LDs) is crucial for elucidating their role in biological function and the pathogenesis of related diseases, including Parkinson's disease (PD). Therefore, developing a fluorescent probe to measure LDs viscosity is crucial. To address the challenges of complex biological environments, a chemical toolbox, F-675, was introduced based on the twisted - intramolecular charge transfer mechanism. F-675 featured a large Stokes shift of 158 nm and emitted near-infrared emission at 675 nm, facilitating LDs detection with minimal biological fluorescent background. Additionally, F-675 exhibited excellent selectivity and sensitivity to changes of LDs. Furthermore, F-675 effectively detected LDs changes in PD models, ranging from cells, C. elegans and Parkin null Drosophila. These findings indicate the potential of F-675 as an effective tool for PD diagnosis.
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