A late-onset neurological disorder: Is progression inevitable? Expert Commentary

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In this month's Movement Disorders Rounds, Dr. Shoaib Dal and colleagues describe an interesting patient with corticobasal syndrome (CBS) thought secondary to discrete asymmetric focal ischemic lesions affecting the cortical and immediate subcortical regions of the hand area of the primary motor cortex [1]. The patient was an 88 year-old right-handed man with a history of coronary artery disease who presented with recurrent presyncopal events and a 2-year history of slowly progressive left-hand clumsiness, tremor, and gait disturbance.