Abstract
Fibroid growth is progesterone-dependent (P4), in part, but the underlying mechanism(s) remain unclear. Previously, we reported that fibroids have elevated levels of AKAP13, an A-kinase anchoring protein that augmented ligand-dependent progesterone receptor B (PR-B) activity. Additionally, we showed a direct and specific interaction between AKAP13 and PR in vitro. Here we further assessed the interaction between AKAP13 and PR as well as functional activation of PR isoforms.
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