Abstract
For decades, biologists have suspected that cancer may be ini t ia ted by a change in the genetic composi t ion of the somatic cell. In pathologic preparat ions, cancer tissues often exhibit a high frequency of abnormal cell d ivis ion figures; so the chromosomes, hence, the genetic const i tut ion, of the cancer cells must be abnormal. However, no one knew whether the abnormal i t ies were the cause or the consequence of neoplasia , and if the abnormali t ies were the cause of cancer, whether or not they were specific. The earliest hypothes is regarding the origin of cancer in relation to cel lular genetics was proposed by Boveri in 1914 [1]. The Boveri hypothesis can be briefly paraphrased as follows.
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