Abstract
The design and application of a high-pressure sample cell is described for circular dichroism studies of molecular systems that undergo conformational change with application of high pressure. Mechanical and optical problems in high-pressure cells, safety considerations in cell design, and the pressurizing system are discussed. Operating procedures developed to yield reproducible data and the results of a trifluoroethanol solution of a derivative of gramicidin A used as an example are outlined.
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