A HIGHLY SENSITIVE C-RE ACTIVE PROTEIN AND ITS REL ATIONSHIP WITH FE ATURES OF ARTERIAL HYPERTENSION IN PATIENTS WITH ABDOMINAL OBESITY

Abstract

The aim: to study the nature of changes in the levels of highly sensitive C-reactive protein(hsCRP) in the blood in patients with arterial hypertension (AH) with abdominal obesity (AO) and their relationship with the characteristics of the course of the disease. Materials and methods. We examined 68 patients with stage II AH (40 men and 28 women) aged from 35 to 60 years (36 patients with AO and 32 –with normal body weight (NBW). The control group consisted of 22 apparently healthy individuals (13 men and 9 women) aged from 18 to 52 years. The survey included standard clinical, laboratory and instrumental methods. The blood levels of hsCRP were determined by the enzyme immunoassay. The data obtained were analyzed using the SPSS 19.0 computer program for Windows XP. Results. It was found that in patients with AH stage II with AO without cardiovascular and renal complications and concominant cardiovascular and renal diseases, a significant increase in blood levels of one of the powerful and sensitive markers of inflammation-hsCRP was revealed, both in comparison with practically healthy individuals, and with patients with AH, but with NBW. The highest blood levels of hsCRP are observed in hypertensive patients with AO with a more pronounced increase in blood pressure, with grade 3 hypertension, with subclinical target organ damage (TOD) specific for hypertension-left ventricular hypertrophy and prediabetes. Conclusions. In stage II AH, which proceeds against the background of AO, but still without any cardiovascular and renal complications and concominant cardiovascular and renal diseases, a pronounced increase in hsCRP production already occurs. An increase in the production of this pro-inflammatory factor can be initiated by both hemodynamic and metabolic changes and lead to early TOD.