Abstract
Intravascular ultrasound imaging systems are effective in identifying and characterizing occlusive arterial disease. In order to investigate changes in vessel wall elasticity due to atherosclerosis, a real-time, high-frequency intravascular ultrasound imaging system has been developed for the study of excised artery sections in vitro. The system consists of a miniature ultrasound probe constructed from a 42-MHz lead zirconate titanate (PZT) transducers, a high-frequency scan converter, and a computer-controlled flow system. By correlating vessel wall displacement, determined from the ultrasound data, with intraluminal pressure variations recorded with a catheter-tip pressure transducer, the elastic properties of the vessel wall can be assessed. Dynamic vessel wall motion along one radial view, assessed using one-dimensional cross-correlation, corresponds well with the simultaneously measured intraluminal pressure waveform. Preliminary studies using a two-dimensional speckle tracking algorithm show potential for determination of regional variation in vessel elasticity.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
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