A Green Approach to the Synthesis of Fused Benzo[1,8]-naphthyridine derivatives by One-pot Three Component Reaction

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One pot synthesis of 3,3-dimethyl-3,4-dihydro-2Hdibenzo [b,g][1,8]-naphthyridin-1-one derivatives has been accomplished by three component protocol involving 2-chloroquinoline-3-carbaldehydes, cyclichexanedione and ammonium acetate as a base catalyst. Mild reaction conditions and good yields are obtained by reaction lying in green approach. This route avoids the use of toxic organic solvents, expensive catalysts and anhydrous conditions. The protocol used narrates the interesting development of highly selective methods for the contruction of Ncontaining heterocycle moiety in aqueous medium reaction.