Abstract
A Grand Challenge in Evolutionary and Population Genetics: New Paradigms for Exploring the Past and Charting the Future in the Post-Genomic era
Highlights
Approaches to evolutionary studies such as ancient DNA and single-cell molecular biology, which once held promise but had fallen by the wayside due to technical limitations, are being revitalized and are changing the way we think about what can be studied
Genomewide association studies (GWAS) have not led to the identification of many genes of large effect, it has helped facilitate personalized disease-risk estimation through new methods focused on combining the smaller effects from many independent loci
Evolutionary and population geneticists benefit from a growing understanding of the functional, phenotypic, and medical effects of genetic variation
Summary
Approaches to evolutionary studies such as ancient DNA and single-cell molecular biology, which once held promise but had fallen by the wayside due to technical limitations, are being revitalized and are changing the way we think about what can be studied. Evolutionary and population geneticists benefit from a growing understanding of the functional, phenotypic, and medical effects of genetic variation.
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