Abstract
One century later: dissecting genetic effects for looking over old paradigms.
Highlights
The foundation of genetics as a scientific field at the beginning of the twentieth century was not free from controversy
The genetic effects comprised the core of that theory, but they were initially implemented in those expressions as parameters neither to be estimated nor to take any defined numerical values
The most parsimonious hypothesis about genetic effects at that time proposed that the genetic basis of quantitative traits is dominated by the effects of large numbers of genes at which allele substitutions have very small and independent effects on phenotype
Summary
The foundation of genetics as a scientific field at the beginning of the twentieth century was not free from controversy. Despite the accumulation of evidences suggesting more complex genetic architectures (e.g., Dobzhansky, 1970), the infinitesimal model proved to be a useful paradigm to guide investigation of practical quantitative genetics. It is not surprising to witness an increased research effort in updating mathematical and statistical tools for analysing genetic effects, aiming to typify all possible kinds of genetic architectures and their evolutionary implications.
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