Abstract
A globally trained equation is suggested for calculating drugs solubility in mono-solvents at different temperatures. The equation is an extension of the van’t Hoff model and includes Abraham, Hansen, Catalan and Laurence parameters as input variables. The accuracy of the proposed equation for calculating the solubility was studied using the average percentage of deviation between the calculated and the experimental values. The solubility data sets were collected from the published papers and used to train the global model and check its accuracy. The provided findings revealed that the equation could be used for the process design computations in the pharmaceutical industry.
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