Abstract
A simple model is proposed for correlating the solubility of a given drug in different mono-solvents at various temperatures. The model is based on the well-known van’t Hoff equation and employs a combination of Abraham, Hansen and Catalan parameters as variables representing the drug-solvent interactions in the solutions. The proposed model correlates the solubility of each drug in different mono-solvents at various temperatures. The accuracy of the model for correlating the data was investigated by calculating the mean percentage deviation of the back-calculated data and the corresponding experimental values. Thirty solubility data sets were collected randomly from the recently published articles. The obtained results are promising and the novel model could be recommended for further investigations.
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