A glimpse of enzymology within the idea of systems

Chuanpeng Liu,Qiming Zhou,Dongjie Fan,Yi Shi

doi:10.1007/s11427-012-4371-2

Abstract

School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China; National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China; Center for Stem Cell and Regenerative Medicine, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201203, China; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China

Highlights

Year will mark the 100th anniversary of the MichaelisMenten equation [1], one of the most important and well known models in enzymology
Because of limitations in available techniques, enzymologists primarily investigate the in vitro properties and catalytic mechanisms of individual enzymes. They often fail to address a fundamental scientific question: how are biological processes, most of which are chemical reactions catalyzed by enzymes, coordinated in space and time to produce a living organism [2]? applications of new techniques and, in particular, wide acceptance of the idea of systems have enabled enzymologists to begin studying enzymes in the context of dynamic, complicated biological systems in recent years
Tu et al [5] reviewed the recent literature on a new family of calcineurin regulators (RCANs), and discussed the molecular mechanism for RCAN-mediated regulation of calcineurin

Summary

Introduction

Year will mark the 100th anniversary of the MichaelisMenten equation [1], one of the most important and well known models in enzymology. Applications of new techniques and, in particular, wide acceptance of the idea of systems have enabled enzymologists to begin studying enzymes in the context of dynamic, complicated biological systems in recent years. These enzymes had been extensively studied, the results presented in three recently published articles indicate that their biological functions are still to be clarified.

Results

Conclusion