Abstract
BackgroundTuberculosis (TB) is caused by a bacterium called Mycobacterium tuberculosis (Mtb). China is the third in top 8 high TB burden countries and Guangxi is one of the high incidence areas in South China. Determine bacterial factors that affected TB incidence rate is a step toward Ending the TB epidemic.ResultsGenomes of M. tuberculosis cultures from a relatively high and low incidence region in Guangxi have been sequenced. 347 of 358(96.9%) were identified as M. tuberculosis. All the strains belong to Lineage 2 and Lineage 4, except for one in Lineage 1. We found that the genetic structure of the M. tuberculosis population in each county varies enormously. Low incidence rate regions have a lower prevalence of Beijing genotypes than other regions. Four isolates which harbored mutT4-48 also had mutT2-58 mutations. It is suggested that strains from the ancestors of modern Beijing lineage is circulating in Guangxi. Strains of modern Beijing lineage (OR=2.04) were more likely to acquire drug resistances than Lineage 4. Most of the lineage differentiation SNPs are related to cell wall biosynthetic pathways.ConclusionsThese results provided a higher resolution to better understand the history of transmission of M. tuberculosis from/to South China. And the incidence rate of tuberculosis might be affected by bacterial population structure shaped by demographic history. Our findings also support the hypothesis that Modern Beijing lineage originated in South China.
Highlights
Tuberculosis (TB) is caused by a bacterium called Mycobacterium tuberculosis (Mtb)
Except for one strain of Lineage1.1.1.1 which originated from Vietnam, Mycobacterium tuberculosis in Guangxi belonged predominantly to sub-lineages L2.1(proto-Beijing), L2.2(Modern- and Ancient- Beijing), L4.2, L4.4 and L4.5
We provided a higher resolution to better understand the history of the transmission of Mycobacterium tuberculosis in South China
Summary
Tuberculosis (TB) is caused by a bacterium called Mycobacterium tuberculosis (Mtb). China is the third in top 8 high TB burden countries and Guangxi is one of the high incidence areas in South China. Determine bacterial factors that affected TB incidence rate is a step toward Ending the TB epidemic. Tuberculosis (TB) is caused by Mycobacterium tuberculosis that most often affect the lungs. Top eight high TB burden countries accounted for two thirds of new TB cases globally in 2019. One of the milestones of the WHO Ending TB Strategy is new TB cases drop 80% by 2030. China is the third in top 8 high TB burden countries and the Guangxi Zhuang Autonomous Region is one of the. We try to characterize the genetic background of the pathogen and figure out some potential associating factors Lin et al BMC Infectious Diseases (2021) 21:840 pathogenicity of M. tuberculosis strains in the hot and cold spot is different. we try to characterize the genetic background of the pathogen and figure out some potential associating factors
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