Abstract
The noncytopathic (nc) mutants of the virulent AV strain of NDV, selected to form hemadsorbing spots but not plaques on chicken embryo cells (1,2) are restricted in viral RNA synthesis, accumulate less L protein intracellularly, and complement with the Group E ts RNA- mutant, but not the Group A ts RNA- mutants of NDV. Plaque-forming revertants of 5 of these mutants show at least partial co-reversion of each of these properties, suggesting that RNA synthesizing capacity and cytopathogenicity are causally related.
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