Abstract
Liquid—solid chromatography (LSC) with mixed mobile phases is discussed in terms of classical thermodynamics. It is shown that a rigorous consideration of solute and solvent competitive adsorption in systems with a non-ideal mobile (bulk) phase and a surface-influenced non-ideal stationary phase leads to a new general equation for the distribution coefficient of a solute involving concurrent adsorption and partition effects. For special sets of parameters this equation reduces to familiar limiting expressions describing either adsorption or partition effects. A detailed discussion is presented for LSC systems with binary phases, in which bulk and surface solutions are assumed to be regular ones.
Published Version
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