Abstract
Five newly obtained hydatidiform moles (complete moles) and lymphocytes from each parent were analyzed for HLA antigen specificities of the A and B loci. The results obtained were not inconsistent with the results observed in 13 cases of complete moles in our first report that mole tissues expressed HLA antigens, and that those specificities were homozygous A and B specificities which were identical to one of the paternal specificities, not the maternal ones. Further, up to date in the literature, the number became 27 cases of complete and invasive moles by adding present ones, where HLA specificities were analyzed. Seventeen cases (22 loci) of the 27 moles had the heterozygous father on the A and/or B loci. These observations confirmed as we suggested in our first report that fertilization of the androgenetic diploid mole with a 46, XX karyotype occurred by a haploid sperm, not a diploid sperm, followed by duplication as a postmeiotic event.
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