Abstract
Collagen has significant contributions to the field of biomedical and tissue engineering applications. Native collagen biomaterials are mechanically feeble and require stabilization against enzymes for multivariate applications. In this study, phytoconstituents are extracted from Artemisia pallens and interacted with collagen for enhancing its chemical properties for biomedical use. From FTIR analysis, it is evident that Artemisia pallens influences the conformational changes, and this change does not affect the stability of collagen, which is ascertained by the electrophoretic study. In the fibrillogenesis study, there is a decrease in the T½ time, which indicates the reduction in the gelling time due to the influence of Artemisia pallens. Histology characterization also confirms the formation of fibrils under the control of Artemisia pallens at a pH < pI. Moreover, anti-glycation activity has been enhanced at a higher concentration owing to its antioxidant characteristics of the phytoconstituents. From the results, it is inferred that influence of Artemisia pallens creates a nucleation center for the monomeric collagen to aggregate in an uniform order, thus stimulating fibrillogenesis and along with its antiglycation activity, Artemisia pallens can assist in establishing a new way in collagen-based biomaterial preparation.
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