Abstract
The melatonin receptor 1B (MTNR1B) polymorphism rs10830963 C>G has been reported to be associated with the risk of gestational diabetes mellitus (GDM) with inconsistent results. To clarify the effect of the polymorphism on the risk of GDM, a meta-analysis therefore was performed. Pooled OR with its corresponding 95%CI was used to estimate the strength of the association. Totally 14 eligible studies with a number of 5033 GDM patients and 5614 controls were included in this meta-analysis. Results indicated that the variant G allele was significantly associated with an increased GDM risk (CG vs. CC: OR = 1.25, 95% CI = 1.11−1.40, P < 0.001; GG vs. CC: OR = 1.78, 95% CI = 1.45−2.19, P < 0.001; G vs. C: OR = 1.33, 95% CI = 1.21−1.47, P < 0.001). In the stratified analysis by ethnicity, similar results were found in Asians (CG vs. CC: OR = 1.15, 95%CI = 1.02−1.28, P = 0.020; GG vs. CC: OR = 1.52, 95% CI = 1.23−1.89, P < 0.001; G vs. C: OR = 1.23, 95% CI = 1.10−1.37, P < 0.001) and in Caucasians (CG vs. CC: OR = 1.40, 95% CI = 1.16−1.70, P < 0.001; GG vs. CC: OR = 2.21, 95% CI = 1.54−3.17, P < 0.001; G vs. C: OR = 1.47, 95% CI = 1.24−1.73, P < 0.001). FPRP and TSA analyses confirmed findings support that the rs10830963 G allele increases the risk of GDM, and further functional experimental studies are warranted to explore and clarify the potential mechanism.
Highlights
Gestational diabetes mellitus (GDM) is defined as abnormal glucose tolerance with onset or first recognition during pregnancy [1]
After full-text reviews of the remaining 26 articles, 12 studies were excluded for the following reasons: 2 studies were case only studies, 3 studies were review or meta-analysis articles, 7 studies didn’t focus on the topic of the Melatonin receptor 1B (MTNR1B) rs10830963 C>G and GDM risk
According to the evaluation of Newcastle–Ottawa scale (NOS) scale, 12 of the included literatures were considered to be of high quality and 2 of them were of low quality
Summary
Gestational diabetes mellitus (GDM) is defined as abnormal glucose tolerance with onset or first recognition during pregnancy [1]. Worldwide, it affects approximately 2–20% of all pregnancies [2]. GDM has been shown to be associated with poor pregnancy outcome and substantial long-term adverse consequences for mothers and their offspring [3–7]. It has been found that the increased expression of MTNR1B on β cells diminished intracellular cyclic cAMP levels, thereby inhibited the insulin secretion [17–19]. These findings suggested that MTNR1B may be involved in the development of GDM
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