Abstract
The lymphotoxin-alpha (LTA) gene has been implicated in the pathogenesis of atherosclerosis. We tested for an association between a functional polymorphism, LTA 252A/G, and common carotid artery intima-media thickness in 1088 siblings from 435 Diabetes Heart Study families. Intima-media thickness was measured by high-resolution B-mode carotid ultrasonography. A MassARRAY system (Sequenom Inc., San Diego, California, USA) was used for genotyping. The LTA 252G allele was positively associated with increased intima-media thickness (the odds ratio for the G allele carriers being in the top tertile of the intima-media thickness distribution was 1.41, P=0.04). The LTA 252A/G polymorphism is moderately associated with sub-clinical atherosclerosis.
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Schedule a callMore From: European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology
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