Abstract
AbstractPacked bed chromatography is among the most important unit operations in bio‐chemical process engineering for purifying target molecules from contaminants. A liquid solution of different species is pumped through the chromatography column, which is filled with porous particles (beads). Solute molecules can adsorb to the inner surfaces of these beads with different affinities which leads to different retention times in the column and consequently facilitates the desired separation.We present a stabilized space‐time finite element scheme to solve for fluid flow and mass transfer in miniaturized chromatography columns, which are used in the design and optimization of industrial‐scale applications. Our method can accurately handle realistic size systems with more than 108 degrees of freedom on massively parallel computing facilities. It can also be applied for simulating sections of larger chromatographic beds in lab‐ and process‐scale columns. (© 2013 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim)
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