Abstract
The assessment of cardiospecific troponins, either troponin I (TnI) or T (TnT), is currently regarded as the mainstay for diagnosing myocardial injury, including acute myocardial infarction (AMI) [ [1] Aldous S.J. Cardiac biomarkers in acute myocardial infarction. Int J Cardiol. 2013; 164: 282-294 Abstract Full Text Full Text PDF PubMed Scopus (84) Google Scholar ]. Although the recent introduction of high-sensitivity troponin immunoassays has contribute to substantially increase the timely and accurate detection of myocardial injury, troponin testing is still plagued by a significant rate of false positive cases, which ultimately contribute to decrease the overall diagnostic specificity of these tests [ [2] Vafaie M. Biener M. Mueller M. et al. Analytically false or true positive elevations of high sensitivity cardiac troponin: a systematic approach. Heart. 2014; 100: 508-514 Crossref PubMed Scopus (34) Google Scholar ]. The leading sources of false positive results of troponin testing include genetic polymorphisms in the TnI and TnT genes which may impair antibody binging [ [3] Lippi G. Cervellin G. Genetic polymorphisms of human cardiac troponins as an unrecognized challenge for diagnosing myocardial injury. Int J Cardiol. 2014; 171: 467-470 Abstract Full Text Full Text PDF PubMed Scopus (7) Google Scholar ], as well as the interference from rheumatoid factor (RF) [ [4] Dupont J. Fromonot J. Franceschi F. et al. A case of false positive troponin elevation: role of the biological laboratory. Int J Cardiol. 2013; 162: e66-e67 Abstract Full Text Full Text PDF PubMed Scopus (7) Google Scholar ], heterophilic antibodies [ [5] Lippi G. Aloe R. Meschi T. Borghi L. Cervellin G. Interference from heterophilic antibodies in troponin testing. Case report and systematic review of the literature. Clin Chim Acta. 2013; 426: 79-84 Crossref PubMed Scopus (60) Google Scholar ] and spurious hemolysis [ [6] Lippi G. Avanzini P. Dipalo M. Aloe R. Cervellin G. Influence of hemolysis on troponin testing: studies on Beckman Coulter UniCel Dxl 800 Accu-TnI and overview of the literature. Clin Chem Lab Med. 2011; 49: 2097-2100 Crossref PubMed Scopus (26) Google Scholar ].
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call