A facile synthesis of 1,2,3-triazolyl indole hybrids via SbCl3-catalysed Michael addition of indoles to 1,2,3-triazolyl chalcones

Abstract

An efficient, facile and environmentally benign synthesis of a library of 1,2,3-triazolyl chalcone hybrids (3a–u) has been accomplished by grinding the reactants at room temperature in excellent yields in very short reaction time. Subsequently, SbCl3 catalysed Michael addition of indoles to the chalcones afford 1,2,3-triazolyl indole hybrids (5a–l) in excellent yields. An efficient, facile and environmentally benign synthesis of a library of 1,2,3-triazolyl chalcone hybrids (3a–u) has been accomplished by grinding the reactants at room temperature in excellent yields in very short reaction times. Subsequently, SbCl3 catalysed Michael addition of indoles to the chalcones afforded 1,2,3-triazolyl indole hybrids (5a–l) in excellent yields.