A green, an efficient and viable approach for the synthesis of novel 4H-pyran-indolin-2-one derivatives via a one-pot reaction by grinding method

Abstract

• A simplistic and rapid protocol using Grinding method. • Synthesis of novel 4 H -pyran-indolin-2-one derivatives. • One-pot/two-component and solvent-free protocol. • Excellent yields (89 to 98%) in short reaction times (< 10 min). An highly efficient and green approach for the synthesis of novel 4 H -pyran-indolin-2-one analogues by the reaction of various isatins with 4 H -pyran-4-one using NaHCO 3 as catalyst under solvent-free, and grinding conditions at room temperature has been showed with good to excellent product yields (89-98%). All the synthesized target compounds has been categorized by various spectroscopic techniques ( 1 H NMR, 13 C NMR, HRMS and FT-IR). This novel protocol has several benefit of mild reaction condition, normal grinding, easy available catalyst, economy, environmentl-friendly, short reaction times (≤ 5 minutes), excellent product yields, and absence of any tedious workup.