A facile synthesis of 1-aryl pyrroles by Clauson-Kaas reaction using oxone as a Catalyst under microwave irradiation

K Gullapelli,G Brahmeshwari,M Ravichander

doi:10.4314/bcse.v33i1.14

K Gullapelli, G Brahmeshwari + Show 1 more

Open Access

https://doi.org/10.4314/bcse.v33i1.14

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Abstract

A new and efficient methodology to synthesize N-substituted pyrrole derivatives by Clauson Kaas reaction employing Oxone as catalyst was developed. The transformation was performed in acetonitrile under microwave irradiation. This procedure has several advantages such as high yield, clean product formation, and short reaction time. KEY WORDS : Synthesis, Pyrrole, Oxone, Microwave irradiation Bull. Chem. Soc. Ethiop. 2019 , 33(1), 143-148 DOI: https://dx.doi.org/10.4314/bcse.v33i1.14

Highlights

The study of heterocyclic compounds is an evergreen field in organic chemistry
The Clauson-Kaas reaction between primary amines and 2,5-dimethoxytetrahydrofuran remains as an attractive possibility [15,16,17,18], which has received great attention because it allows the synthesis of pyrroles without substituents on the carbon atoms of the heterocycle
A new methodology for the synthesis of 1-aryl pyrroles 3 has been described by a Clauson-Kaas reaction employing three-component synthesis of pyrrole derivatives by using catalytic amount of Oxone

Summary

Introduction

The study of heterocyclic compounds is an evergreen field in organic chemistry. It always attracts the attention of scientists working in the area of natural compounds and in synthetic organic chemistry, with Nitrogen containing heterocyclic structural unit exhibits a wide range of biological activities through effective binding to enzyme receptor site.As per the present research reports, thousands of new heterocyclic compounds either isolated from natural sources or synthesized in the laboratories are added to the literature every year. The study of heterocyclic compounds is an evergreen field in organic chemistry. It always attracts the attention of scientists working in the area of natural compounds and in synthetic organic chemistry, with Nitrogen containing heterocyclic structural unit exhibits a wide range of biological activities through effective binding to enzyme receptor site. Many of these compounds have drawn the attention in various fields like natural product synthesis, functional materials, ligands, biological and pharmacological activities [1,2,3,4,5,6].

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Conclusion