Abstract
A new procedure to synthesize the N-substituted pyrrole derivatives by Clauson Kaas reaction catalyzed by acidic ionic liquid under microwave irradiation was developed. This procedure provides several advantages such as high yield, clean product formation, and short reaction time.
Highlights
Pyrrole derivatives have great importance in organic chemistry, because they are present in many compounds which were natural, medicinal, and agricultural products and semiconductor polymers [1,2,3]
We wish to report here the clean, short time synthesis of N-substituted pyrrole derivatives by the Clauson Kaas reaction catalyzed by acidic ionic liquid, 1-hexyl-3-methylimidazolium hydrogen sulfate ([hmim][HSO4]), under microwave irradiation
The acidic ionic liquid [hmim][HSO4] was prepared under microwave irradiation starting from [hmim][Br] according to the literature procedure [45], and the spectral data of the compound were in accordance with the reported data [46]
Summary
Pyrrole derivatives have great importance in organic chemistry, because they are present in many compounds which were natural, medicinal, and agricultural products and semiconductor polymers [1,2,3]. Various pyrrole syntheses have been reported in the literature [8,9,10,11,12,13,14,15] One of these methods is Clauson Kaas pyrrole synthesis which uses 2,5-dimethoxytetrahydrofuran as four-carbon source. Ionic liquids (ILs) have been widely used in organic reactions as solvent due to their advantages such as negligible vapor pressure, variable polarity, and good solvating ability [24,25,26]. We wish to report here the clean, short time synthesis of N-substituted pyrrole derivatives by the Clauson Kaas reaction catalyzed by acidic ionic liquid, 1-hexyl-3-methylimidazolium hydrogen sulfate ([hmim][HSO4]), under microwave irradiation. Found: C, 62.76; H, 7.21; N, 9.15
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