Abstract
Uniform hollow magnetic mesoporous silica spheres (HMMS), with Fe3O4 nanoparticles embedded in the mesoporous shell, were successfully prepared by using carboxylic polystyrene latex and Fe3O4 heteroaggregates as the hard template together with a coating of tetraethoxysilane (TEOS) and n-octadecyltrimethoxysilane (C18TMS) mixture. The HMMS outer diameter is about 370 nm and the thickness of the mesoporous shells is around 20 nm. Both the morphology and the thickness of the shell can be easily tuned by tailoring the amount of PS latex and the concentration of ammonia. Meanwhile, the magnetic properties can be slightly changed by adjusting the weight ratios of PS/Fe3O4. In addition, the HMMS demonstrates high drug storage capacity and sustained release properties, demonstrating that this kind of HMMS could be used as a promising material in drug delivery systems.
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