A facile, green, one-pot synthesis of amidoalkyl naphthols under solvent-free conditions catalyzed by a carbon-based solid acid

Abstract

An efficient, environmentally friendly procedure for the synthesis of amidoalkyl naphthols through the one-pot, three-component reaction of β-naphthol, aryl aldehydes, and acetamide in the presence of a carbon-based solid acid under thermal solvent-free conditions is described. The beneficial features of this new synthetic approach include short reaction time, high yields, clean reaction profiles, and a simple work-up procedure. Furthermore, the catalyst can be readily recycled and reused four times without obvious significant loss of activity. The structure of the catalyst was confirmed by Fourier transform infrared spectroscopy, N 2 adsorption/desorption analysis, and X-ray diffraction. An efficient method for the synthesis of amidoalkyl naphthols via the solvent-free, one-pot, three-component reaction of β-naphthol, aryl aldehydes and acetamide in the presence of a carbon-based solid acid (CBSA) as a reusable heterogeneous catalyst is described. The structure of the catalyst was confirmed by FT-IR, BET and XRD techniques.