A Facile and in situ Preparation Technique for Solid-Phase Microextraction Fibers with MOFs Coating

Abstract

In this study, a facile preparation technique for in situ growth of MOFs-based-coated solid-phase microextraction (SPME) fibers is proposed. NH2-MIL-53 can be grown on the Al wire simply by immersing the Al wire in the solution of growth seeds and metal–organic frameworks (MOFs) successively, thereby obtaining the SPME fiber. The as-prepared fiber was combined with gas chromatography flame ionization detection (GC-FID) for the determination of non-steroidal anti-inflammatory drugs (NSAIDs) in water samples. Compared with NH2-MIL-53-coated fiber prepared with the gluing method, MIL-53-coated fiber prepared by in situ self-growth and commercial polyacrylate (PA) fiber, the as-prepared fiber demonstrated the better extraction performance, owing to more exposed adsorption sites and stronger interactions with the target. Moreover, the fiber exhibited a long service life due to multifaceted stability. After optimization of extraction and desorption conditions, the analytical method had a low-detection limit (0.002–0.05[Formula: see text][Formula: see text]g[Formula: see text]L[Formula: see text], a wide linear range (0.01–500[Formula: see text][Formula: see text]g[Formula: see text]L[Formula: see text] and good reproducibility (relative standard deviation [Formula: see text]5.84%) and provided good results for actual water samples. MOFs-based SPME fibers grown on metal wires using a facile in situ technique can maximize the extraction advantage of MOFs coating, which well promotes the application and development of MOFs in solid-phase microextraction technology.