Abstract
A facile one-pot four-component domino protocol has been successfully developed for the combinatorial synthesis of novel N-methyl-3-nitro-4-aryl-4H-pyrano[2′,3′:4,5]imidazo[1,2-a]pyridine-2-amine 7 and 2-amino-4-aryl-4H-pyrano[2′,3′:4,5]imidazo[1,2-a]pyridine-3-carbonitrile 8. The protocol employs readily available starting materials, leading to high yields of the products (83–89%). The transformation involves a domino Knoevenagel-intramolecular Michael reaction sequence, enabling the formation of three new bonds (two CC, two CN, and one CO) and two rings in a single step. Notably, this reaction exhibits several remarkable features, including short reaction time, eliminating the need for extensive workup and column chromatographic purification. Additionally, the reaction demonstrates good scalability, producing satisfactory yields even on a gram-scale.
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