Abstract
Objective To study negative450(N450), positive slow wave(PSW)during a specific cognitive task with conflict and visual P3 in patients with schizoprenia. Methods The electrophysiological correlations between Stroop color-word paradigm and oddball paradigm in 18 patients with schizophrenia and 16 healthy controls were compared with the reaction time(RT), accuracy rate and event related potentials(ERP)extracted from EEG data. Results Behavioral results showed in Stroop paradiam(consistent stimulus vs. inconsistent stimulus)that patients' RTs((643 ± 129)ms vs.(733 ± 123)ms)were significantly prolonged(F=12.689, P=0.001)than controls((525 ± 42)ms vs.(592 ± 61)ms)and accuracy rates in patients(93% ± 11% vs. 90% ± 12%)were significantly lower(F=4.353, P=0.049)than that in controls(99% ± 1% vs. 97% ± 2%). In oddball paradiam(non-taget stimulus vs.taget stimulus)only the patients' RTs((419 ± 75)ms vs.(512 ± 111)ms)were significantly prolonged(F=8.174, P=0.008)than that in controls((361 ± 45)ms vs.(425 ± 49)ms). ERPs showed in Stroop tasks N450 amplitude inpatients was significantly larger than that incontrols((6.4 ±0.6)μV vs.(6.1±0.8)μV, F=3.081, P=0.047), and the PSW in the patients was much unsteady. In visual oddball task, the P3 amplitude in patients was significantly reduced(F=4.657, P=0.042), but no difference in RTs. Conclusions At least in simple tasks, executive function deficit of patients with schizophrenia may not caused by slowly perceiving and categorizing but by slowly selecting, preparing, or executing the appropriate response. In complicate task, the patients' reaction may be slow from preceiving stage till the end of executive process. Key words: Schizophrenia; Event-related potentials, P300; Stroop test; Executive function
Published Version
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