Abstract
As vital microenvironmental indicators, hypochlorite and viscosity levels can be applied to diagnose diseases. Thus, real time and in situ monitoring of hypochlorite and viscosity has gained increasing attentions. A fluorescence probe named JDK was developed by using a novel acceptor of 2-(2-(5-(dimethylamino)thiophen-2-yl)vinyl)-1,3,3-trimethyl-3H-indol-1-ium fluorophore basing on FRET and TICT system. JDK possessed large Stokes shift, broad emission peak gap, prominent photostability and biocompatibility. JDK could track hypochlorite with rapid response time (within 1 min) and low detection limit (28.5 nM). Meaningfully, JDK was favor to append on mitochondria where physiological processes can be disrupted deriving from the abnormal concentrations of hypochlorite and viscosity. Successfully, JDK could visualize endogenous hypochlorite and viscosity in living cells and zebrafish.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
