Abstract
Dynamic light scattering (DLS) is an effective tool for measuring the distribution of the size of particles. In this work, we design a novel integrated dual-angle DLS prototype which incorporates microfluidic chip and fiber optic probes to achieve measurement at high concentration and a small amount of sample consumption(30 μl). The experimental results show that for the suspension with concentrations up to 14 mg/ml, the instrument can achieve high accuracy (relative error less than 6%). Particle size prediction at a series of concentration is calibrated using linear regression model in machine learning. Furthermore, we firstly implement dual angle on-line measurement in the fiber DLS system with microfluidic chip. The experiment results show improved repeatability of dual-angle DLS when compared with single-angle DLS measurement.
Published Version
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