Abstract
A randomised double-blind trial was undertaken in a hundred and fortysix patients with acute myocardial infarction to determine whether low-dose subcutaneous heparin reduced the frequency of deep-venous thrombosis (D.V.T.) in the legs. Low-dose heparin (5000 units 12-hourly) started within 12 hours of the onset of myocardial infarction and continued for 10 days significantly reduced the frequency of D.V.T., diagnosed by the 125I-fibrinogen technique, from 17·2% in the control group to 3·2% in the heparin-treated group. There were no complications of heparin treatment. Since the relation between the prevention of D.V.T., detected with 125I-labelled fibrinogen, and the prevention of pulmonary embolism is uncertain, it would seem reasonable to embark on a larger trial to determine whether the frequency of pulmonary embolism could be reduced with low-dose heparin.
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