Abstract
Epidemiological studies show chronic marijuana users have poorer outcomes for both physical health and psychosocial functioning. Evidence has shown that a potential mechanism of action for marijuana's effect is the endogenous cannabinoid system and the active compound Δ9-tetrahydrocannabinol (THC). There is mounting evidence that marijuana withdrawal has clinically identifiable symptoms which follow a time course typical of other substance withdrawal syndromes. Substitution strategies are a typical treatment strategy in addiction treatment. Nabilone [Cesamet®] is a synthetic cannabinoid that may mediate the effects of marijuana; however this has not been evaluated in humans. Therefore, we assessed the safety of Nabilone [Cesamet®] in subjects using marijuana. Subjects were randomized into treatment (n = 22) and control (n = 22) arms, and received a three-week, daily dose of Nabilone [Cesamet®] at 1 mg/day or placebo. Safety outcomes consisted of vital signs, hematology, ECG, urinalysis, and adverse events...
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