A dose-response analysis on the association of body mass index and hyperuricemia among physical examination aged 30-60 adults in a hospital in Beijing

Abstract

Objective To investigate the dose-response relationship between body mass index (BMI) and hyperuricemia (HUA) among aged 30-60 adults in Beijing. Methods A questionnaire survey was conducted on 8 866 adults in Beijing Electric Power Hospital in 2012.Multivariate logistic regression and restricted cubic spline methods were used to explore the relationship between BMI and hyperuricemia management and dose-response analysis. Results Among 8 866 participants, there were 5 623 males (63.4%) and 3 243 females (36.6%). The prevalence rate of HUA was 18.4%, and male was higher than female (24.9% vs. 7.1%). Age, sex, smoking, BMI, blood pressure (BP), glucose and serum lipid level were significantly different (all P<0.05). After adjusting for factors such as age, smoking, BP, glucose, total cholesterol, triglyceride, HDL-C and LDL-C, results showed that overweight men (OR=1.68, 95%CI: 1.42-1.99), obesity men (OR=2.16, 95%CI: 1.76-2.65), overweight women (OR=1.59, 95%CI: 1.15-2.20) and obesity women (OR=2.77, 95%CI: 1.79-4.27) had increased the risk of HUA (all P<0.0001). Restricted cubic spline analysis showed a non-linear dose-response relationship between the continuous change in BMI and hyperuricemia in the male population (χ2=15.49, P=0.0004) and a linear relationship in female (χ2=0.57, P=0.7521). Conclusions There is a certain correlation between continuous changes of BMI and HUA. A non-linear relationship is found in male and a linear relationship was found in female. Key words: Hyperuricemia; Overweight; Obesity; Restricted cubic spline