Abstract
Abstract The objective of this study was to compare the analgesic and side effects of three different doses of lidocaine for intravenous regional analgesia (IVRA). Thirty-six New Zealand white rabbits were used for the study. Rabbits were randomly divided into three groups. Group I received 0.5% lidocaine (3 mg/kg), Group II received 1% lidocaine (6 mg/kg), Group III received 1.5% lidocaine (9 mg/kg). Onset time of analgesia in Group III was significantly shorter than in Groups I and II. The durations of motor blockade and analgesia increased significantly in a dose dependent manner. In all the groups, there were statistical significance increases of sedation scores after tourniquet removal. Significant dose dependent reductions of heart and respiratory rates after tourniquet release were observed. In conclusion, 6 and 9 mg/kg lidocaine given intravenously produced a shorter onset time of IVRA, and a longer analgesia and motor blockade than 3 mg/kg without life threatening complications.
Published Version
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