Abstract
Acne vulgaris is considered as a disorder of pilosebaceous unit of the skin, and the mechanisms is still obscure. Kyoto Rhino Rat (krh) was made in mutagenesis by ethylnitrosourea (ENU) which is a chemical mutagen at Institute of Laboratory Animals Graduate School of Medicine Kyoto University. Krh is an excellent candidate of a new model for acne vulgaris with abnormality of hair follicle and sebaceous glands.Krh were used in this study at 12 weeks of age (n=12). Comedone were mildly seen at 12 weeks of age of krh.
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